Bisubstrate Inhibitor 78 from Cayman Chemical

An NNMT inhibitor (IC50 = 1.41 µM); binds the NNMT active site in the binding pockets for SAM and nicotinamide; selective for NNMT over NSD2 and PRMT1 (IC50s = >50 µM for both); reduces MNA levels in, and inhibits proliferation of, HSC-2 oral cancer cells at 100 µM