Description
A bivalent Smac mimetic and IAP antagonist; binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively); induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells at 5 µM; induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells at 4 µM; enhances radiosensitization and increases apoptosis in HCC193 and H460 NSCLC cell lines; induces cell death in a panel of 40 primary, patient-derived BCP-ALL samples at 1 µM; increases survival and time to relapse in a high-risk BCP-ALL PDX mouse model