Description
A gp130 modulator; increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM); reduces BMP4-induced cellular apoptosis and hypertrophy in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes; reduces cartilage loss in a rat model of osteochondral injury at 4 µg/joint