Description
A positive allosteric modulator of the mGluR5; potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG, and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 µM for human and rat mGluR5, respectively); potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of STN neurons