Description
An inhibitor of P-gp; selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance; resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel; reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells; prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells; prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel