Description
An NMDA receptor antagonist (IC50 = 36 nM); selective for the NMDA receptor over sigma receptors (IC50 = 2,540 nM); reduces infarct volume and the number of steps and errors in a foot fault test in a rat model of stroke induced by middle cerebral artery occlusion at 1 mg/kg; reduces cortical and striatal neuronal necrosis in a rat model of temporary focal ischemia at 1.13 mg/kg