Description
An activator of Nrf2 signaling; increases the expression of Nrf2 target genes and activates HO-1 in CV-1 cells at 100 nM; binds to PPARγ and PPARα (Kis = 344 and 232 nM, respectively) and induces PPARγ transactivation in SW480 cells; inhibits NOS production in isolated mouse macrophages (IC50 = 0.014 nM); inhibits proliferation of U937 and MCF-7 cells at 300 nM; reduces fatty acid synthesis in LiSa-2 human liposarcoma cells at 100 nM; reduces tumor growth in a B16 murine melanoma model at 50 µg/animal twice per day