Description
An activator of autophagy; inhibits mTORC1 signaling by covalently binding to the lysosomal v-ATPase; selective for inhibition of mTORC1 over mTORC2 signaling; increases lysosome acidification and increases cellular clearance of TDP-43 protein aggregates in a v-ATPase-dependent manner in U2OS osteosarcoma cells; inhibits mTORC1 signaling and enhances autophagy in mouse skeletal muscle and heart at 50 mg/kg