Description
An NMDA receptor antagonist (Ki = 0.14 µM); binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits (Kis = 0.04, 0.3, 0.6, and 2 µM, respectively); inhibits NMDA-induced depolarizations in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2); inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 µmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 µmol/kg)