Description
A PDGFR family kinase inhibitor (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRβ, CSF1R, FLT3, and c-Kit, respectively); >30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of 5 CYP enzymes (IC50s = >40 µM); inhibits CSF1R-dependent M-NFS-60 murine leukemia cell proliferation and reduces tumor volume in an FLT3 mutant MV4-11 leukemia mouse xenograft model at 30 mg/kg