Description
A DNA alkylating agent; inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 cells at 10 µM; reduces tumor growth in a C6 rat glioma model at 0.3 and 6.7 mg/kg; reduces the number of amyloid-β plaques and brain levels of Aβ40, as well as increases brain levels of sAPP in the APP/PS1 transgenic mouse model of Alzheimer’s disease at 0.5 mg/kg, i.p