Description
An iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities; reverses erastin-induced ferroptosis in HT-1080 fibrosarcoma cells at 100 µM; reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes at 200 and 50 µM, respectively; reduces cholesterol diet-induced increases in the levels of Aβ42, Aβ40, and the phosphorylation of tau and GSK-3β in the rabbit hippocampus at 50 mg/kg