Description
A prodrug form of MLN2238; inhibits the 20S proteasome (IC50 = 8.4 nM for the human enzyme); binds to caseinolytic protease P (Kd = 7,300 nM for the S. aureus enzyme); inhibits the proliferation of RPMI-8226, U266B, and ARH-77 cells (IC50s = 49.4, 67, and 43.5 nM, respectively)