Description
An antiosteoporotic agent; inhibits 1,25-dihydroxyvitamin D3-induced increases in the levels of carbonic anhydrase II and the vitronectin receptor, markers of osteoclast differentiation, in isolated chicken bone marrow cells at 0.1, 0.5, and 1 mM; pretreatment or continuous treatment of bovine bone slices at 1 mM inhibits bone resorption by isolated rat osteoclasts; decreases osteoclast surface and number but has no effect on the bone formation rate or mineral apposition rate in the alveolar bone in adult cynomolgus monkeys at 750 mg/kg per day