Description
A PD-1/PD-L1 interaction inhibitor; inhibits the PD-1/PD-L1 interaction in a TR-FRET assay (IC50 = 6-100 nM); reduces LPS-induced increases in PD-1 levels and apoptosis in MH-S mouse alveolar macrophages at 1 µM; surgical neointimal patching with PD-1/PD-L1-coated patches decreases neointimal thickness and inflammatory cell accumulation in a rat model of patch angioplasty