Description
A DGK-α inhibitor (IC50 = 300 nM in isolated platelet plasma membranes); increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets; inhibits PDGF-induced DGK-α activity in intact VSMCs; inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner; prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy