Description
A γ-secretase modulator; selectively inhibits AICD cleavage to Aβ over Notch cleavage to NICD at 1 µM in luciferase assays; inhibits DHCR24 activity in primary rat hepatocytes and HepG2 cells (IC50s = 11 and 15 nM, respectively); reduces Aβ42 production in primary rat embryonic cerebral cortex neurons (IC50 = 220 nM); decreases Aβ42 levels in guinea pig brain and CSF at 100 mg/kg