Description
An anilinopyrimidine fungicide; inhibits the biosynthesis of methionine in phytopathogenic fungi; inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s = 0.44, 4.8, and 0.03 µM, respectively); an estrogen receptor agonist (EC20 = 1.91 µM); inhibits the androgenic effect of DHT (IC20 = 15.1 µM); increases proliferation of estrogen receptor-expressing BG-1 ovarian cancer cells at low micromolar concentrations in combination with 17β-estradiol; increases tumor mass in a BG-1 ovariectomized mouse xenograft model after 70 days at 3 mg/kg every three days