Description
A saponin with antiviral and anticancer activities; an inhibitor of OSBP and its paralog ORP4 (Kis = 16 and 71 nM in radioligand binding assays using HEK293T cell lysates); inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM); inhibits replication of CVB3 in infected HeLa R19 cells in an OSBP-dependent manner at 3 nM; protects against CVA9 and echovirus 2 infection in HeLa cells at 10 nM; inhibits replication of HCV but not MHV, a coronavirus; inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively)