Description
An eIF4E inhibitor; inhibits proliferation of JEKO-1 and Mino MCL, MCF-7 and MDA-MB-231 breast, AGS gastric, and OE19, OE33, and LFO-1 esophageal cancer cell lines (GI50s = 9.8-12.2 nM); reduces expression of cyclin D1 and c-Myc, markers of eIF4E activity, in breast and MCL cancer cell lines in a dose-dependent manner; induces expression of the pro-apoptotic proteins p53 and cleaved caspase-3