Description
A sesquiterpene lactone; inhibits the growth of SKOV3, LOX-IMVI, A549, MCF-7, HCT15, and PC-3 cancer cells (IC50s = 1.1-8.7 µg/ml); inhibits HCV replication in Huh7.5 cells (EC50s = 0.4-1.4 µM for genotypes 1a, 1b, 2b, 3a, 4a, 5a, 6a, and 7a); inhibits release of TNF-α and NO from LPS-stimulated RAW264.7 cells (IC50s = 8.24 and 1.1 µM, respectively) as well as LPS-induced lymphocyte proliferation (IC50 = 0.9 µM); inhibits the growth of T. cruzi bloodstream trypomastigotes isolated from infected mice (EC50 = 1 µg/ml); exhibits antifeedant activity against S. granarius beetles, T. confusum larvae, and T. granarium larvae