ABT-737 from Cayman Chemical

Product Specs
ItemABT-737
CompanyCayman Chemical
Price $266.00Supplier Page View Company Product Page
Catalog Number11501
Quantity25 mg
FormatA crystalline solid
Molecular Weight813.4
Purity≥98%
TypeInhibitors
Research AreaApoptosis, Cancer, Cell Death
Storage-20
FormulaC42H45ClN6O5S2
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Induction of caspase-mediated suppression of interferon signaling potentiates viral oncolysis of resistant tumor cellsCell Communication and SignalingMarch 24, 2026Vladimir Bozhdansky, Shelly Tayar, Shlomi Kashkash, Eran Bacharach, Marcelo Ehrlichconcentrations: JAKi (Baricitinib, BioVision, cat. #2842), 4 µM; Abt737 (Cayman Chemical Company, cat. #11501), 5 µM; QVD-OPH (Apexbio Technology LLC, cat. #A8165), 20 µM; human IFNα2 (PBL-assay science, cat. #111051),

(2) Large transient assemblies of Apaf1 constitute the apoptosome in cellsNat CommunOctober 24, 2025Alicia C. Borgeaud, Iva Ganeva, Calvin Klein, Amandine Stooss, Daniela Ross-Kaschitza, Liyang Wu, Joel S. Riley, Stephen W. G. Tait, Thomas Lemmin, Thomas Kaufmann, et al.ratio of 1:2 or 1:3, according to the manufacturer’s instructions. Whenever used, ABT-737 (Cayman, 11501) was added to the culture medium at a concentration of 10 μM. Whenever used, the caspase inhibitor Q-VD-OPh

(3) Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cellsNature immunologyJanuary 1, 2025Holley CL, Monteleone M, Fisch D, Libert AES, Ju RJ, Choi JH, Condon ND, Emming S, Crawford J, Lawrence GMEP, et al.apoptosis, BMDMs were left unprimed and intrinsic apoptosis was induced with ABT-737 and S63845 (cat. nos. 11501 and 21131, Cayman Chemical, both used at 500 nM) for 2 h. To activate the CASP4 inflammasome in HBECs,

(4) Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid LeukemiaCancers (Basel)December 15, 2023Johnson Ung, Su-Fern Tan, Todd E. Fox, Jeremy J. P. Shaw, Maansi Taori, Bethany J. Horton, Upendarrao Golla, Arati Sharma, Zdzislaw M. Szulc, Hong-Gang Wang, et al.HL-60/VCR [23] were supplemented with 1 μg/mL vincristine sulfate (Cayman, #11764). ABT737 (Cayman, #11501) was supplemented to ABT737R cell lines: HL-60/ABT737R [24] (5 μM ABT737); KG-1/ABT737R and KG-1a/ABT737R

(5) Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane PermeabilizationMolecular cellJuly 2, 2020Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, et al.mucosa,Sigma Aldrich,Cat# P6887 S63845,MedChemExpress,Cat# HY-100741 ABT-737,Cayman Chemical,Cat# 11501 Lipofectamine 3000,ThermoFisher Scienfici,Cat# L3000008 BIM SAHBA2,Walensky Lab,N/A BAX α6 SAHB,Walensky

(6) Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAXCell reportsMarch 10, 2020Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD.-Sodium L-ascorbate,Sigma-Aldrich,Cat# A7631 S63845,MedChemExpress,Cat# HY-100741 ABT-737,Cayman Chemical,Cat# 11501 BIM SAHBA2,Walensky Lab,N/A Recombinant BAX WT,Walensky Lab,N/A Recombinant BAX C62A,Walensky Lab,N/A Recombinant

(7) Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid LeukemiaMolecular cancer research : MCRMarch 1, 2020Pearson JM, Tan SF, Sharma A, Annageldiyev C, Fox TE, Abad JL, Fabrias G, Desai D, Amin S, Wang HG, et al.sulfate (Cayman #11764). HL-60/ABTR (34) cells were maintained in the presence of 5 μM ABT-737 (Cayman #11501). KG1/ABTR and KG1a/ABTR (34) cells were maintained in the presence of 1 μM ABT-737. Kasumi-6 and SNKO1

(8) Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and TumorigenesisTheranosticsJanuary 1, 2020Yang P, Xie J, Li Y, Lin HP, Fenske W, Clementino M, Jiang Y, Yang C, Wang Z.All 16HBE cells were cultured in minimal essential medium (MEM) supplemented with 10% FBS. ABT-737 (#11501), wortmannin (#10010591), rapamycin (#13346), cycloheximide (Chx) (#14126), and MG132 (#10012628) were

(9) Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosiseLifeFebruary 4, 2019Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski22426) was used for cellular staining at 20 nM. Drug treatments used were ABT-737 at 10 µM (Cayman 11501) and Q-VD-OPh at 10 µM (APExBIO A1901). Live-cell confocal microscopy HeLa cells were grown in two-well

(10) Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosisElifeFebruary 4, 2019Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski22426) was used for cellular staining at 20 nM. Drug treatments used were ABT-737 at 10 µM (Cayman 11501) and Q-VD-OPh at 10 µM (APExBIO A1901). Live-cell confocal microscopy HeLa cells were grown in two-well

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ABT-737 from Cayman Chemical

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Cayman Chemical

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ABT-737 from Cayman Chemical

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