Description
A peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay); selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes of µ-opioid receptors (Ki = 13.8 nM); inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively); induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.)