Description
A potent inhibitor of hedgehog signaling (IC50 = 20 nM in a Shh-LIGHT2 assay); blocks binding of BODIPY-cyclopamine to cells expressing Smo in a dose-dependent manner; cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum; inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells; decreases the expression of nuclear Gli1 and cytosoloic MMP-9, pERK1, and pERK2 proteins in a dose-dependent manner; increases TRAIL-mediated cell death in NCH82 and NCH89 human glioblastoma cultures; upregulates expression of DR4 and DR5 in LN229 and U251 glioma cells