Description
An anticancer agent; inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cancer cells (IC50s = 4.6 and 3.4 µM, respectively); inhibits S to G2 and G2/M to G1 cell cycle progression; decreases tumor volume and increases survival in a Lewis lung carcinoma mouse model at 44 mg/kg; decreases tumor volume in an HNC-3 head and neck cancer xenograft mouse model at 40 mg/kg; exhibits reduced nephrotoxicity in rats compared with cisplatin