Description
An IFNAR2 agonist with antiviral activity (EC50 = 200 nM in an anti-HCV replicon assay); exhibits 1:1 binding to the IFNAR2 extracellular domain; induces expression of IFN-stimulated genes without induction of genes encoding inflammatory cytokines and chemokines in vitro and in vivo; reduces HCV titer in HCV-infected humanized liver mice following oral administration