Description
An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner; inhibits fMLP- or IL-8-induced neutrophil migration (IC50s = 0.64 and 0.24 µM, respectively); reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg