Description
A CNS depressant; reduces transmission through the sympathetic ganglia, decreasing electrically stimulated contractile responses in feline nictitating membrane; reduces coordinated locomotor activity in mice by >50% in mice at 71, 142, and 213 mg/kg; decreases hyperactivity induced by pipradol, D-amphetamine, morphine, and cocaine; increases the duration of hexobarbital-induced sleeping time; a metabolite of terfenadine formed via CYP3A4