Description
An inhibitor of the protein-protein interaction between SAP and amyloid fibrils (IC50 = 0.9 µM); crosslinks with pentameric SAP in the plasma to form a decameric complex, which is eliminated via hepatic clearance; induces the dissociation of SAP from tissue amyloid deposits, leading to its redistribution into the plasma, where it is eliminated; serum human SAP levels in a transgenic mouse model of amyloidosis at 1 mg/ml in the drinking water