Description
A PI4KIIIβ inhibitor (IC50 = 19 nM); selective over PI4KIIIα and PI4KIIα; inhibits PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively); reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells; inhibits intracellular ceramide transport