Description
A mGluR1 antagonist (IC50 = 5.1 nM for the human receptor); selective for mGluR1 over mGluR2, mGluR5, and mGluR8 (IC50s = >10, 7, and >10 µM, respectively); decreases methamphetamine-induced hyperlocomotion in mice at 0.3 mg/kg and reverses disruptions in prepulse inhibition induced by methamphetamine and ketamine in rats at 1 mg/kg