Description
A 5-HT2B receptor antagonist; binds to 5-HT2B receptors (Ki = 3.4 nM); inhibits 5-HT-induced MAPK activation and thymidine incorporation in CHO cells expressing human 5-HT2B (IC50s = ~12 and ~3 nM, respectively); reduces peak pulmonary arterial pressure and right ventricular hypertrophy in a rat model of MCT-induced pulmonary hypertension at 50 and 100 mg/kg