Description
An inhibitor of voltage-gated sodium channels (IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1- Nav1.8 channels); has state-dependent activity at the Nav1.7 channel (IC50s = 6.3 and 54 µM for open/inactivated and closed/resting states); decreases pain behavior in an OD1 mouse pain model