Description
A selective inhibitor of BRD7 and BRD9 (Kds = 99 and 909 nM, respectively); selective for BRD7/9 over a panel of 48 BRDs up to 10 µM; inhibits BRD7 interactions with H3.3 and H4 (IC50s = 3.7 and 3.3 µM, respectively); inhibits BRD9 interactions with H3.3 and H4 (IC50s = 5.1 and 6.2 µM, respectively); decreases IL-6 levels in LPS-stimulated THP-1 cells