Description
An adenosine A2A receptor antagonist; selective for adenosine A2A over A1 receptors (Kis = 2.3 and 107 nM, respectively, in radioligand binding assays); inhibits agonist-induced production of cAMP in CHO cells expressing adenosine A2A receptors (IC50 = 353 nM); reduces haloperidol-induced catalepsy in mice at 10 and 20 mg/kg; reduces the number of jaw tremors in a rat model of tacrine-induced Parkinsonian jaw tremors; increases locomotor activity and reverses motor disabilities in a marmoset model of MPTP-induced Parkinson’s disease at 20 and 40 mg/kg