Description
An anticonvulsant; inhibits the activation of Nav1.1 at 100 µM; inhibits Nav1.1, but not Nav1.2, Nav1.3, and Nav1.6, opening and increases the action potential threshold in primary rat hippocampal neurons; inhibits CAVA (Ki = 343.8 nM) but not CAI and CAII (Kis = >10,000 nM for both); prolongs the preictal phase and reduces seizure-like event frequency in an in vitro model of epileptiform activity in rat hippocampal slices at 100 µM; inhibits pentylenetetrazole-induced seizures in a mouse model of epilepsy (ED50 = 54 mg/kg, i.p.); reduces kainic acid-induced neuronal cell death in the mouse hippocampal CA3 region when used at doses of 25, 50, and 100 mg/kg