Description
A GPR75 antagonist; increases basal GPR75 protein levels and inhibits 20-HETE induced reductions in GPR75 protein levels in PC3 cells; reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells at 5 and 10 µM; reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension at 10 mg/kg per day