Description
An inhibitor of skeletal muscle myosin II ATPase activity; inhibits calcium-stimulated ATPase activity of rabbit muscle myosin S1 in an actin-independent manner (IC50 = ~5 µM); is selective for calcium-stimulated myosin II over human platelet myosin II, kinesin, pyruvate kinase, and lactate dehydrogenase at 100 µM; inhibits the activity of skeletal muscle myosin, reversibly reducing the sliding velocity of heavy meromyosin in a gliding-filament assay at 2 µM; inhibits isometric calcium-activated tension in isolated fast-twitch rabbit psoas muscle fibers (IC50 = ~3 µM); an intermediate in the synthesis of sulfonamides