Description
An inhibitor of LMW-PTPA (IC50 = 0.8 µM); selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by >50% at 40 µM; increases insulin-induced insulin receptor phosphorylation in HepG2 cells at 10 µM; improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity at 50 mg/kg per day