Description
A dual inhibitor of PI3K and BRD4 (IC50s = 16, and 241 and 1,550 nM for PI3K, and BRD4 bromodomains 1 and 2, respectively); reduces MYCN gene expression and decreases MYCN and cyclin D1 protein levels; inhibits phosphorylation of Akt in SKNBE2 cells; reduces tumor volume and protein levels of MYCN and cyclin D1 in a MYCN-amplified SKNBE2 neuroblastoma xenograft model in mice; reduces tumor growth and the number of colonic lymph node metastases in the murine orthotopic pancreatic Panc02 carcinoma model