Description
A quassinoid with diverse biological activities; active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 µg/ml, respectively); inhibits radish seed germination by 88% when used at a concentration of 1 mM; inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 cells at 0.1 µM; reduces tumor volume in 22Rv1, LNCaP, and VCaP CRPC mouse xenograft models at 2 mg/kg