Description
A β3-AR agonist; induces cAMP accumulation in CHO cells expressing the β3-AR but not the β1- or β2-AR (EC50s = 0.0224, >10, and >10 µM, respectively); reduces carbamoylcholine-induced contraction of isolated rat and human bladder strips (EC50s = 5.1 and 0.78 µM, respectively); decreases the frequency of isovolumetric rhythmic bladder contractions in anesthetized rats at 3 mg/kg