Description
A tubulin polymerization inhibitor; inhibits proliferation of A549, H1299, and H226 human NSCLC cells (IC50s = 0.041, 0.046, and 0.041 µM, respectively), as well as adriamycin-resistant NCI/ADR cells that overexpress P-glycoprotein (IC50 = ~0.03 µM); induces cell cycle arrest at the G2/M phase and apoptosis in A549 cells at 0.3 µM; reduces tumor growth in an A549 mouse xenograft model when administered in combination with erlotinib