ML-290 from Cayman Chemical

An RXFP1 agonist (EC50 = 0.094 µM for the human receptor in a cAMP production assay); selective for RXFP1 over RXFP2 (EC50 = 1.5 µM); induces expression of VEGF in THP-1 cells expressing human RXFP1 at 250 nM; stimulates cAMP release from HEK293 cells expressing the human, macaque, pig, or rabbit receptors, but not the guinea pig or mouse receptors; increases the expression of MMP1 and PPARGC1A and decreases COL1A1 expression in primary human hepatic stellate cells at 5 µM; reduces carbon tetrachloride-induced liver fibrosis in transgenic mice expressing human RXFP1 at 37 mg/kg