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Protein Biochemistry
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PIK-III
PIK-III from Cayman Chemical
Be the first to write a review!
Citations:
(5)
Supplier Page
Supplier Page from
Cayman Chemical for
PIK-III
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Description
A selective inhibitor of Vps34 (PI3K type 3; IC50 = 18 nM); acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
PIK-III
Company
Cayman Chemical
Price
$242.00
Supplier Page
View Company Product Page
Catalog Number
17002
Format
A crystalline solid
Research Area
Autophagy, Cell Biology, Cell Signaling, Endomembrane System & Vesicular Trafficking, PI3K/Akt/mTOR Signaling
Molecular Weight
319.4
Quantity
5 mg
Purity
≥98%
Storage
-20
Formula
C17H17N7
Origin
CHN
Type
Inhibitors
Add to Compare List
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (5)
(1)
Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis
Nature cell biology
July 1, 2023
Alkhoury C, Henneman NF, Petrenko V, Shibayama Y, Segaloni A, Gadault A, Nemazanyy I, Le Guillou E, Wolide AD, Antoniadou K,
et al
.
inhibitors
were used: SAR405 (Selleckchem, S7682),
Vps34-IN1
(
Selleckchem
,
S7980
) and
PIK-III
(
Cayman
,
17002
). The adenoviral vectors expressing
shRNA
targeting
Bmal1
and
Bmal1
were described previously63. The
(2)
Inhibitors of VPS34 and lipid metabolism suppress SARS-CoV-2 replication
bioRxiv
September 6, 2022
Jesus A. Silvas, Alexander S. Jureka, Anthony M. Nicolini, Stacie A. Chvatal, Christopher F. Basler
(
ThermoFisher
). Cells were then processed for
confocal
analysis. Compounds VPS34 IN-1 (#
17392
),
PIK-III
(#
17002
),
Triacsin C
(#
10007448
), and
Orlistat
(#
10005426
) were purchased from
Cayman Chemical
(Ann Arbor, Michigan).
(3)
Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation
Cell reports
November 23, 2021
Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, Tabata K, Bartenschlager R.
,
Sigma Aldrich
,Cat#
B1793
PI4KA-G1,"Gift from V. Lohmann (Bojjireddy et al., 2014)",N/A
PIK-III
,
Cayman Chemical
,Cat#
17002
Remdesivir
,
MedChemExpress
,Cat#
HY-104077
EBSS,Sigma Aldrich,Cat#E2888 ,, Critical commercial
assays
,Critical
(4)
Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition
Molecular cancer therapeutics
October 1, 2018
Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H,
et al
.
autophagy inducer [rapamycin (
Sigma
#
R8781
)], an early-stage autophagy
inhibitor
[PIKIII (
Cayman
Chem #
17002
)], and two late-stage autophagy
inhibitors
[
bafilomycin A1
(
Sigma
#
SML1661
and LC Labs #B-1080 in Figure
(5)
Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication
Cell reports
January 1, 0001
"Williams CG, Jureka AS, Silvas JA, Nicolini AM, Chvatal SA, Carlson-Stevermer J, Oki J, Holden K, Basler CF."
to highly disruptive editing
techniques
like multi-guide. Compounds
VPS34 IN-1
(#
17392
),
PIK-III
(#
17002
),
Triacsin C
(#
10007448
),
Orlistat
(#
10005426
),
TOFA
(#
10005263
),
C75
(#
10005270
),
Etomoxir
(#
11969
),
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PIK-III from Cayman Chemical
Supplier Page
View Company Product Page
$242.00
Product Specs
Company Info
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