Description
An NSAID and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively); inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner; inhibits fMLP- or A23187-induced calcium influx in PMN (IC50s = 29 and 14 µM, respectively); activates various ion channels, including TRPC6 and KCa1.1; inhibits various ion channels, including TRPC3 and CFTR; reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae at 20 mg/kg