Description
An allosteric mGluR7 agonist; inhibits forskolin-induced cAMP accumulation in CHO cells expressing human mGluR7b (EC50 = 64 nM); selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits at 10 µM; binds to NET and α1-AR; increases the proliferation NPCs and induces their differentiation into neurons at 1 µM; inhibits apomorphine-induced circling in a 6-OHDA-induced PD rat model at 2.5 mg/kg