Description
A substituted quinoline with neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities; maintains GSH levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a TEAC assay; protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro (EC50s = 7 and 200 nM, respectively); renoprotective in a SAMP8 mouse model of chronic kidney disease associated with rapid aging at 10 mg/kg per day starting at nine months of age