Description
An adenylyl cyclase 1 inhibitor (IC50 = 2.3 µM); inhibits AC1 activation induced by A23187, forskolin, or isoproterenol in vitro; selective for AC1 over other membrane-bound AC isoforms; enhances the inhibition of AC1 by the MOR agonist DAMGO in vitro; reduces hypersensitivity to touch in mouse hind paw (ED50 = 0.28 µg) in a mouse model of inflammatory pain