Description
A TLR3 antagonist (IC50 = 3.44 µM); selective for TLR3 over TLR4, TLR2/6, TLR1/2, and TLR7 at 27 µM; inhibits dsRNA binding to TLR3 (Ki = 2.96 µM in a fluorescence anisotropy assay); decreases poly(I:C)-induced production of TNF-α and IL-1β in RAW 264.7 cells at 27 µM